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The anti-cancer drug called 'Sunitinib' is being developed by Pfizer Inc. It is used to treat gastrointestinal stromal tumours – a type of tumours that grow in the stomach, intestine or esophagus, the tube that connects the throat with the stomach in people.

The new drug is one of a family of new and powerful anti-cancer drugs called tyrosine-kinase inhibitors, which target key molecular pathways thought to encourage tumour growth. Other drugs in this family include imatinib, better known as Gleevec, and dasatinib (Sprycel), health portal HealthDay reported.

Scientists led by Ming Hui Chen, an assistant professor of medicine at Harvard Medical School and a cardiologist at Children's Hospital, Boston, studied 75 patients with stomach tumours that had not responded to the standard therapy with Gleevec.

The patients had taken part in a trial studying the efficacy of Sunitinib. The researchers looked back at the medical records of the studied patients, noting those who died from heart disease or had suffered heart attacks or congestive heart failure.

They also looked at the effect of Sunitinib on the heart's ability to pump blood and on blood pressure. Chen's team found that eight patients given repeated cycles of Sunitinib had cardiovascular events.

Two had heart attacks, and six had heart failure. Of the 36 patients given the approved dose of Sunitinib, 10 had a 10 percent or more reduction in the ability of their heart to pump blood, and seven had a 15 percent or more reduction in heart function.

In addition, Sunitinib was associated with increases in blood pressure, with a total of 35 (47 percent) of the patients developing hypertension, the scientists said in their findings published in the Dec 15 issue of The Lancet.

However, these effects were not permanent: When Sunitinib treatment was stopped and patients began therapy to ease heart problems, levels of heart failure and heart functioning improved, they said.

In addition, Chen's team found that Sunitinib triggered heart cells' damage and death when they experimented that drug on mice and rat heart cells.

The drug maker Pfizer Inc. agreed that these heart risks do exist. However, they added that the cardiovascular events were medically manageable in most patients.

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Washington, Jan 12 (ANI): A growth factor, called PDGFR, which is a common target of cancer drugs, has been found to play an important role in the heart’s response to stress, according to researchers at The University of Texas M. D. Anderson Cancer Center.

In many cancers, the body makes too much platelet-derived growth factor receptor (PDGFR), a type of protein that controls cell growth, allowing cancer cells to increase uncontrollably.

Several chemotherapy agents, including Sutent(r) (sunitinib), Nexavar(r) (sorafenib) and Gleevec(r) (imatinib), work by targeting and inhibiting PDGFR.

This slows the growth of cancer – as well as angiogenesis, which is the growth of new blood vessels.

“Recently, some of these targeted anti-cancer drugs have been associated with heart failure. But the role of PDGFR signaling in the heart has been largely unexplored until now,” said Dr. Aarif Khakoo.

In the study, the researchers showed that, while PDGFR-inhibiting agents may slow the growth of cancer cells, they also may impair the heart’s ability to respond to stress.

Since these agents also often cause elevated blood pressure, this causes a double bind of added stress to the heart and lessened capacity to deal with this stress.

Using special laboratory mice with limited cardiac PDGFR and mice with normal PDGFR signaling, researchers performed transverse aortic constriction (TAC)- a procedure widely used to study heart disease in which a band is placed at the aortic arch, resulting in acute pressure overload.

And they found that the mice with limited PDGFR had heart failure.

“We showed that cardiomyocyte PDGFR expression and activation in heart muscle cells rises dramatically in response to pressure overload stress. Furthermore, we showed that knockout of PDGFR in heart muscle results in cardiac dysfunction, heart failure and a marked defect in stress-induced cardiac angiogenesis,” said Khakoo.

They also demonstrated that PDGFR signalling is crucial in the creation of new blood vessels that help the heart respond to stress.

The study opens the door to studying additional effects of PDGFR-inhibiting drugs on the heart, as well as ways to prevent damage to the heart.

“Patients with pre-existing heart disease may be at increased risk for cardiomyopathy and heart failure associated with these drugs. If we can confirm this, it might help develop a tool to determine the individual risk for cancer patients being considered for treatment with PDGFR inhibitors and to develop strategies to prevent heart damage,” said Khakoo.

The study has been published in the Journal of Clinical Investigation. (ANI)

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US President gave a speech to the American Medical Association trying to get the organization's members on board with his plans for healthcare rethought. By the way, the problem of healthcare reform continues to be not easy theme in Congress, and the road to laws is sure to be not short and filled with much debate. So, to assist Washington in the process, or after all to keep the politicians sane with a little entertainment, we've come up with a little healthcare download movies online free marathon .

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Young Doctors in Love download movies online free (1982)

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Free health care clinics and providers in Brooklyn, New York – If you are looking for free and reduced cost health care in Brooklyn New York I have complied a list of great resources for you. If you need a free health care clinic is Brooklyn New York free the best place for you is called The Brooklyn Free Clinic.

The Brooklyn Free clinic offers free full and primary health care to adults over 18 who do not have medical insurance. The Brooklyn Free Clinic is run entirely by volunteers that include physicians, student physicians and other health care professionals.

Some of the free services they offer are: Yearly Checkups, Health maintenance visit for chronic illness and diseases such as Cholesterol, Diabetes, High blood pressure, Sick visits *Note they do not see emergency patients.

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The Brooklyn Health Clinic will also help to see if you qualify for other free health insurance programs like Medicaid.

The Brooklyn Free Clinic is located at the Throop Avenue Clinic Site in Bedford-Stuyvesant:

613 Throop Avenue, Brooklyn, NY 11216

Phone: (347) 920-8379 www.brooklynfreeclinic.org

Bedford Stuyvesant Family Health Center

Offers health care on a sliding scale. Some of the services they provide are Pediatric care, Family Planning (Birth Control), Cardiology, Podiatry, Drug abuse assessment, HIV care, Dentistry, urology, Men's health and Women Health. The Bedford Stuyvesant can also help you receive free or low cost prescription drugs.

The Bedford Stuyvesant Family health care is located at

1413 Fulton Street

Brooklyn, NY 11216

Phone: 718-636-4500

Hours: Monday 8-7; Tuesday8-4; Wednesday 8-4; Thursday 8-5; Friday 8-4 www.bsfhc.com

Mobile Health Vans – Community Healthcare Network has 2 mobile vans that offer free health care.

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Call 646-296-1122 for location times nearest you www.chnnyc.org/locations/mobile/

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94-98 Manhattan Avenue

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Phone: 718-388-0390

The hours are Hours: Monday, Thursday and Friday 9-5; Tuesday 10-6; Wednesday 9-8. Saturday 9-4. They are closed on Sundays. www.chnnyc.org/locations/cabs

Caribbean House Health Center offers care for the entire family

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1167 Nostrand Avenue

Brooklyn, NY 11225

Phone: 718-778-0198

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Bushwick Clinic offers free family planning services including: STD Services, Emergency Contraception, Hepatitis B vaccine, Hepatitis A vaccine for high risk patients, Hepatitis C screening for high risk patients, HIV Counseling and Rapid Testing

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335 Central Avenue (between Linden St and Grove St)

Brooklyn, NY 11221

Monday – Friday – 8:30am to 4:00pm

Calling 311 is a great place to turn for help. They can help point you in the right direction for the services you need.

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